An Unbiased View of pkrrating
The interfacial residues are really conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements demonstrate that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations support a product the place activating RNA serves for a scaffold to bind multiple PKR monomers, raisin